Saturday, June 22, 2013

Officials: Suicide attack kills 4 northern Iraq

BAGHDAD (AP) ? Officials say a suicide car bomb in northern Iraq has killed at least four people.

A police officer says the bomber rammed his explosive-laden vehicle into a police patrol in a village outside the city of Mosul on Saturday morning. He says that three civilian bystanders and one policeman were killed, and six people were wounded. Mosul is 360 kilometers (220 miles) northwest of Baghdad.

A medical official confirmed the casualty figures. Both officials spoke on condition of anonymity as they were not authorized to release information.

With violence spiking sharply in recent months to levels not seen since 2008, al-Qaida in Iraq and other militant groups have been gathering strength in Mosul and surrounding cities.

Source: http://news.yahoo.com/officials-suicide-attack-kills-4-northern-iraq-085528210.html

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Ex-inmate recalls Gandolfini?s quiet support

James Gandolfini (AP)James Gandolfini (AP)James Gandolfini, who passed away on Tuesday, will long be remembered for his consummate acting chops. For wrongly convicted Marty Tankleff of Long Island, however, the "Sopranos" star left an entirely different kind of legacy.

Years after Tankleff was convicted as a teenager for killing his parents in 1988, Gandolfini became a quiet supporter of the Long Islander as he fought for two decades to overturn the double-murder charge, the New York Daily News reports.

?Jim was loyal?it wasn?t like he did it for the publicity,? said Tankleff, 41.

Gandolfini learned about the case through Jay Salpeter, a former New York Police Department detective, while researching a role for the 2006 movie "Lonely Hearts." Gandolfini met Tankleff soon afterward, driving several hours upstate to see him at Great Meadow Correctional Facility.

?He was a genuine, nice person you could sit down and eat dinner with,? said Tankleff. ?He got involved with my situation when others were reluctant.?

At the upstate facility, Gandolfini spent two hours talking with Tankleff and showed up to support him in a Brooklyn courtroom two months later. While the actor declined to do media interviews, Lonnie Soury, the PR executive who led the campaign to free Tankleff, told the Daily News that his presence alone delivered a powerful, unspoken message.

?My feeling was we were going to have a friend for the life of Marty?s case,? recalled Salpeter

Tankleff?s sentence was overturned by an appeals court in December 2007. According to the Daily News, Tankleff is a now a paralegal working toward a law degree.

Source: http://news.yahoo.com/blogs/lookout/gandolfini-leaves-legacy-support-ex-inmate-135820547.html

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We Are All Someone Else?s Fleas

Fernando Torres of Spain competes with Jonathan Tehau of Tahiti during the FIFA Confederations Cup Brazil 2013 Group B match between Spain and Tahiti at the Maracana Stadium on June 20, 2013 in Rio de Janeiro, Brazil.

Fernando Torres of Spain competes with Jonathan Tehau of Tahiti during a FIFA Confederations Cup group match on Thursday in Rio de Janeiro, Brazil.

Photo by Jasper Juinen/Getty Images

It would have annoyed Jonathan Swift to know that posterity would think of him as an Irish writer, since he considered himself thoroughly English. Born in Ireland to English parents, brought up in Ireland and educated in England, it was his bad luck to be an outsider in both countries: an Irishman in England and an Englishman in Ireland. Forced to settle for a clerical post in Dublin, which he saw as a provincial backwater, Swift had plenty of time to brood on perspective. In 1726, he published the perspective-shifting masterpiece by which he is remembered, Gulliver?s Travels.?

In brief: Dr. Lemuel Gulliver voyages to the South Seas. He is shipwrecked and washes up on the island of Lilliput, which turns out to be populated by tiny people whose affairs Gulliver regards with amused condescension. Later he again blunders off course and winds up in Brobdingnag, land of the giants, where he is reduced to the status of a performing monkey at the court.?

Swift gives the location of Lilliput as somewhere near Van Diemen?s Land, which is modern Tasmania. Brobdingnag is in the Pacific, 500 leagues east of Indonesia.?

Both countries would today be members of the Oceania Football Confederation.?

Oceania is characterized by immense watery expanses and stupendous gulfs in footballing ability that could not be much wider if Lilliput and Brobdingnag were actual members. It is the home of the double-digit score line, a land where drubbings are commonplace.

In the rest of the world, such massive margins of victory are extremely rare. Inventing the sport gave England a 50-year head start in international football, but they?ve still only won by scoring 10 or more goals five times in 141 years. Before Thursday?s 10?0 win against Tahiti, Spain had done it twice in 93 years.

Tahiti have done it 14 times. Last year they crushed Samoa 10?1 on their way to winning the Oceania Nations Cup, running in four goals in the last 15 minutes. Half the nations of Oceania have at some point writhed under the Tahitian lash. Guam, 14?0. Micronesia, 17?0. American Samoa, 18?0. The Cook Islands, 30?0.

To put Tahiti?s 14 double-digit wins in perspective, the regional superpower, Australia, managed only 10 such results before becoming exasperated with the low standard of competition and applying for a transfer to the Asian Football Confederation.?

Among the big beasts of the Confederations Cup, Tahiti are kittens?but back home that kitten is a bloodthirsty monster that toys with its prey before exterminating it. Having beaten up on so many smaller teams themselves, Tahiti knew what fate might await them at the Maracana.?

When Gulliver is in Lilliput, he feels a great responsibility not to injure or offend his tiny hosts by throwing his gigantic weight around. Some felt that the Spanish national team were confronted with a similar dilemma.

Spain were the world champions and the greatest international team to play the game. Tahiti had one full-time professional player. Would Spain risk looking ungentlemanly?even ridiculous?if they set about Tahiti with all the strength at their disposal?

The question suggests an unfamiliarity with the peculiar ethics of football. The Spanish internationals mostly play for the two giant clubs that dominate one of the world?s most unfair leagues. They know that soccer is a jungle where the strong crush the weak. The ?mercy rules? common in American kids? sports are alien to the spirit of the game. Mercy in that context means pity, and pity is contempt in disguise. Teams often ease off on a beaten opponent to conserve their own energies, but there?s no law of sportsmanship that says they have a duty to preserve the opponent?s honor?that?s the opponent?s job.

Collectively, Spain?s goal was to defend their own prestige, and that meant beating Tahiti by at least as wide a margin as Nigeria had in the last game. Individually, the Spanish attackers knew that here was a chance to pad their international stats. When they count up your goals at the end of your career, nobody will complain that a chunk of them were scored against Tahiti. There was also personal pride at stake?no Spanish forward wants to walk off the field having failed to score against a team of delivery men and PE teachers.

Source: http://www.slate.com/articles/sports/sports_nut/2013/06/spain_tahiti_confederations_cup_2013_spain_s_10_0_victory_reveals_that_we.html

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Thursday, April 25, 2013

Postpartum Mood Disorders | talkhealth Blog

Postpartum depression itself is nothing new but the culture of support surrounding women who suffer from this disorder is. Until recently, many women didn?t feel comfortable opening up about their struggles with postpartum depression because it was often seen as a sign of weakness in a new mother. Now that more women are discussing the disorder and communication in the media has increased, awareness has also increased, which has done much to dispel the misconception that postpartum depression isn?t real or that, if it?s real, it?s a rare disorder. According to the Centers for Disease Control and Prevention, Postpartum Depression (PPD) affects 10%-15% of mothers within the first year of giving birth and up to 80% of women experience a less severe form of the disorder often called the ?baby blues.?

Educate yourself about the risk factors, symptoms and treatments with the following facts and tips to make your transition into motherhood a joyous one.

Postpartum mood disorders are caused by hormonal changes, fatigue and disrupted sleep patterns. While many of these issues can?t be avoided, you can better protect yourself by knowing if you have risk factors that could increase the severity of these issues.

Risk factors for postpartum depression:

  • Previous episodes of depression or postpartum depression
  • A family history of or current mood disorders like depression and bipolar disorder
  • Other stressful life events at the same time as pregnancy or immediately following birth
  • A lack of support from partner, family and friends

Symptoms of postpartum mood disorder:

  • Frequent crying spells
  • Mood swings
  • Insomnia or trouble sleeping
  • Sadness about your baby
  • Confusion, irritability and inability to concentrate
  • Overwhelming emotions
  • Noticeable weight gain or loss
  • Loss of appetite
  • Feelings of hopelessness or anxiety

Many symptoms may disappear on their own with time. If they don?t or if they become more severe, there are treatment options available, such as antidepressants, psychotherapy and hormone therapy. Here are some tips that you can do yourself to alleviate many of the symptoms of postpartum depression.

  • Remain social. Stay in touch with your loved ones and friends. Isolation makes depression much worse. Schedule activities, visits, lunches or play dates that get you out of the house and talking to other people.
  • Get plenty of sunshine. Don?t shut yourself away or stay in the dark. Open the windows and throw back the curtains to let sunshine in. If you can, get outside at least two times a day.
  • Eat a nutritious, well-balanced diet. If your appetite is low, try to eat small, healthy snacks throughout the day to boost your energy level. Stay away from alcohol and caffeine, if you find yourself using them as a way to feel better.
  • Stay active.? Regular exercise boosts endorphins and helps you feel both physically and mentally healthier. Incorporate your baby into your exercise routine by going on stroller walks around the neighborhood.
  • Listen to music. ?Stimulating music will help energize you during the day and soothing music can help you relax at night. It will do the same for your baby.
  • Get plenty of rest. If your baby is up during the night, try to sleep when he/she sleeps during the day. Fatigue and lack of sleep can increase depression.
  • Join a support group for new moms in your area. These groups are a great way to spend more time with your baby outside of the home where you can learn about motherhood and connect with people who are going through the same experiences as you.
  • Ask for help. If your family and friends are offering to help, don?t say no. Loved ones can help alleviate some of the stresses of everyday tasks.

Postpartum Psychosis is an extremely rare yet serious postpartum mood disorder. If you experience hallucinations, irrational speech or thoughts of harming your child or yourself, you should contact your doctor or call emergency services immediately.

There are many free, confidential, 24-hour?hotlines available for anyone that is experiencing even the smallest issues. These hotlines can help you get the help you need, whether through a support group, emergency services or therapy. Remember that you are not alone and should not be ashamed to get postpartum depression treatment if you are experiencing postpartum mood disorders or any issues regarding your maternal health.

Post written by?NorthShore University HealthSystem -??visit for more information on postpartum depression treatment.

Source: http://www.talkhealthpartnership.com/blog/2013/04/postpartum-mood-disorders/

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Stacey Campfield Won't Apologize for Pressure Cooker Photo, Slams "Tasteless" Gun Control Efforts

Source: http://www.thehollywoodgossip.com/2013/04/stacey-campfield-refuses-to-apologize-for-pressure-cooker-photo/

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The BeagleBone Black Is A New Single-Board Computer That Can Brew Beer

beaglebone-specs-640x444While the Raspberry Pi is great for educating kids about computing, can it brew a mean beer? The BeagleBone Black can. Trevor Hubbard, an engineer at Texas Instruments, uses the new, next-gen board to control heat exchangers and monitors to handle beer temperature remotely.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/I1VCofOTpx8/

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Gunmen seize Sunni town in central Iraq

BAGHDAD (AP) ? Gunmen have taken over a Sunni town north of Baghdad after a firefight with security forces, exacerbating Iraq's recent turmoil, the country's Defense Ministry said on Thursday.

The seizure of the town of Suleiman Beg follows clashes between soldiers and Sunni protesters on Tuesday that set off fighting in Sunni towns in western and northern Iraq, leaving more than 100 people dead in clashes and other violence across the country since then. The unrest is heightening fears that Iraq could slide into full-scale sectarian fighting.

In its statement, the Defense Ministry said gunmen have taken control of the Suleiman Beg police station and other governmental buildings, and were deployed in the streets. It gave no other details on casualties.

On Wednesday, police and hospital officials reported fierce clashes in the town that resulted in the deaths of four soldiers and 12 others, including some gunmen.

The mayor of the city of Tuz Khormato, to which Suleiman Beg is administratively annexed, said security forces had laid siege to the small town and sporadic clashes were continuing Thursday. The official, Shalal Abdool, said there were further casualties among gunmen on Thursday, but he couldn't give numbers.

The town is about 150 kilometers (90 miles) north of Baghdad.

Meanwhile in the northern city of Mosul, clashes erupted late Wednesday between gunmen and police in some districts. The fighting died down by Thursday morning after security forces brought the situation under control. Residents said the city is now largely quiet with?many people staying home in fear.

Ten gunmen and four police officers were killed in the Mosul clashes, and 12 policemen were wounded, according to police and morgue officials. They spoke on condition of anonymity because they weren't authorized to release the information.

The turmoil is exacerbating an already sour political situation between Sunnis and the Shiite-led government. A Sunni politician who recently announced his resignation from the Cabinet on Thursday urged Prime Minister Nouri al-Maliki, a Shiite, to step down to calm the tensions.

"Iraq is in a dire situation now and that I believe that there must be serious solutions," Abdul-Karim al-Sammarraie told The Associated Press in a phone interview. "One of the solutions is the resignation of the prime minister and for him to leave the government to another who can run it temporarily. Otherwise the options for Iraq are only dangerous ones."

Al-Sammarraie is Iraq's minister of science and technology. He and Minister of Education Mohammed Tamim submitted their resignations this week in the wake of killings on Tuesday in the northern town of Hawija, where government forces cracked down on a protest leaving at least 23 dead including three soldiers. The government says those who were killed were militants who were using the protest grounds as a safe haven.

Al-Sammarraie said that Industry Minister Ahmed al-Karbouli also submitted his resignation. Al-Karboli was not reachable, but an official in his office confirmed the move. The official spoke on condition of anonymity because he was not authorized to make statements about the resignation to the media.

___

Follow Sinan Salaheddin on twitter.com/sinansm

Source: http://news.yahoo.com/gunmen-seize-sunni-town-central-iraq-115957828.html

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More for Less 04/30 by MOTC | Blog Talk Radio - Internet Radio

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    The Down & Dirty welcomes Megan Massacre, co-star of NY Ink and America's Worst Tattoos on TLC. She's also an alternative model, a DJ, and an amazing artist.

  • Kate Middleton?s big day may be history, but the impact of her gown lives on, says fashion consultant Monica Barnett: ?Off-white and lace are all the rage.?

  • Long before Jodie Foster sort of came out, Debra Chasnoff outed herself when accepting an Academy Award. The details on SnowbizNow!

  • Rob Anthony Dire presets singer, songwriter, Joshua Adams to discuss his upcoming album. Joshua is currently in 1st place in the VeeWall vocal contest.

  • Ancient civilizations researcher and popular author Frank Joseph will discuss his new book "Before Atlantis: 20 Million Years of Human and Pre-Human Cultures".

  • Eastern Michigan LB Justin Cudworth joins Fan Junkies Radio the day before the NFL Draft to talk about his dreams of being drafted into the NFL on Thursday.

  • Tom Levenson, filmmaker & Prof of Science Writing at MIT hosts Maryn McKenna, science writer specializing in public health, global health and food policy, author of Beating Back the Devil & Superbug.

  • Janet Love welcomes Dr. David Hanscom, Author of Back in Control to discuss A Spine Surgeon's Roadmap out of Chronic Pain!

  • Janice Stanger, author of The Perfect Formula Diet talks about how a plant-based diet protects against the effects of toxic chemicals.

  • Living By Design brings NY Times Bestselling author, Dr Iyanla Vanzant, Host of "Fix My Life", OWN Network, to the show.

  • Largest Mall in N. America, Travel Brigade hits the West Edmonton Mall to stay in themed suites at Fantasyland Hotel, try slides at World Waterpark and more!

  • Doctors of the USA welcomes Terry Foster, a certified health nutritional counselor and owner of The Skinny Pantry, to talk about the truth and facts of gluten.

  • Johnny Solinger joins the show lead singer of Skid Row & Solinger about his diverse musical career and new country single "Rock n Roll Cowboy Man"

  • Biggest Loser Resort doc, Dr. Ray DiBartolomeo, joins host Michele Rosenthal to chat about how chiropractic methods can reduce stress.

  • San Diego's big bass lakes are on the bite, The Eastern Sierra Trout Opener is this weekend and there is no limit CRAZY striper fishing too.

  • Alisa Boniello is a retro-soul, pop starlet who is making lots of noise in the Indie music world with her latest release, Can't Love Me.

  • Hay House author & Best Ever You CEO and Founder, Elizabeth Hamilton-Guarino and Dr. Katie Eastman for a live teleseminar "A Recipe for Being Your Best You."

  • David Busby and Carlos Torres join me for a discussion of DFW sports, from the Rangers to the Mavericks to the Stars and Cowboys.

  • KiKi Richardson welcomes Blue Kimble of BET's The Game and VH-1's Single Ladies for, "Men Tell ALL!"

  • Michele Price brings you weekly access to the top minds in Business Success Mindset and Web 2.0 tools with industry giants including Geoff Livingston.

  • Drew Emborsky (a.k.a. The Crochet Dude?) talks to us about his career as a designer, teacher, and as an icon in the fiber arts world.

  • Live with Lesley Paterson, current Xterra World Champion. Lesley is an accomplished triathlete and coach and will be talking about sports and life.

  • Source: http://www.blogtalkradio.com/unified-communications/2013/04/30/more-for-less

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    Wednesday, April 24, 2013

    'Red line': Chemical weapons in Syria

    By Maayan Lubell

    JERUSALEM (Reuters) - Syrian government forces have used chemical weapons - probably nerve gas - in their fight against rebels trying to force out President Bashar al-Assad, the Israeli military's top intelligence analyst said on Tuesday.

    Brigadier-General Itai Brun made the comments at a Tel Aviv security conference a day after U.S. Defense Secretary Chuck Hagel said on a visit to Israel that U.S. intelligence agencies were still assessing whether such weapons had been employed.

    U.S. President Barack Obama has called the use of chemical weapons a "red line" for the United States that would trigger unspecified U.S. action.

    "To the best of our understanding, there was use of lethal chemical weapons. Which chemical weapons? Probably sarin," Brun said in the most definitive Israeli statement on the issue to date.

    Photos of victims showing foam coming out of their mouths and contracted pupils were signs deadly gas had been used, he said.

    Forces loyal to Assad were behind the attacks on "armed (rebels) on a number of occasions in the past few months, including the most reported incident on March 19", Brun said.

    The Syrian government and rebels last month accused each other of launching a chemical attack near the northern city of Aleppo.

    On Monday, Hagel said the use of chemical weapons by Assad's forces would be a "game changer" and the United States and Israel "have options for all contingencies".

    Hagel met Prime Minister Benjamin Netanyahu in Jerusalem on Tuesday, a day after flying in an Israeli military helicopter over the occupied Golan Heights on the edge of the fighting in Syria that has entered its third year.

    "This is a difficult and dangerous time, this is a time when friends and allies must remain close, closer than ever," Hagel, in remarks to reporters before his talks with Netanyahu, said about the United States and Israel.

    IMPASSE

    Discussions between Syria and the United Nations on a U.N. investigation of possible use of chemical weapons have been at an impasse due to the Syrian government's refusal to let the inspectors visit anywhere but Aleppo, diplomats and U.N. officials said last week.

    U.N. diplomats said Britain and France had provided Ban's office with what they believed to be strong evidence that chemical weapons also had been used in the city of Homs.

    Israel, which has advanced intelligence capabilities that it shares with its Western allies, has voiced concerned that parts of Syria's chemical arsenal would end up in the hands of jihadi fighters or the Lebanese guerrilla group Hezbollah, with which it waged a 2006 war.

    Israel leaders have cautioned they will not allow that to happen. In an attack it has not formally confirmed, Israeli planes bombed an arms convoy in Syria in February, destroying anti-aircraft weapons destined for Hezbollah.

    Brun, who was speaking at the annual security conference of The Institute for National Security Studies at Tel Aviv University, said Israel's military was studying a number of future scenarios facing Syria.

    "More likely, as time goes by, are the scenarios of chaos and anarchy, or that of (Syria) breaking up into cantons. These pose major challenges for Israel. The chance of a different central government still exists, but it is growing less likely with time," Brun said.

    (Additional reporting by Jeffrey Heller and David Alexander; Editing by Jeffrey Heller and Alison Williams)

    Source: http://news.yahoo.com/israeli-general-says-syria-government-forces-used-chemical-074330220.html

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    Stocks gain on earnings; fake tweet shakes stocks

    NEW YORK (AP) ? Companies that do the best when the economy is improving led the market higher Tuesday after several of them reported strong quarterly earnings.

    Coach, a maker of luxury handbags, and Netflix, which streams TV shows and movies over the Internet, were winners after announcing profits that impressed investors. Financial stocks rose after Travelers' earnings beat the expectations of financial analysts who follow the company.

    That's a change from earlier this year. The stock market's surge in 2013 has been led by so-called defensive industries such as health care, consumer staples and utilities. Investors buy those stocks when they're unsure about the direction of the economy and want to own companies that make products people buy in bad times as well as good. Until now, they've been less enthusiastic about stocks of companies that provide discretionary goods and services and do best in good times.

    "For a change we are actually seeing more cyclical parts of the economy lead the market," said Michael Sheldon, chief market strategist at RDM Financial Group.

    The Dow Jones industrial average and the Standard & Poor's 500 index both rose 1 percent, and for a third straight day.

    Stocks closed higher even after financial markets were shaken in the early afternoon when a fake tweet on The Associated Press Twitter account prompted a sudden sell-off.

    A posting saying that there had been explosions at the White House and that President Barack Obama had been injured was sent at 1:08 p.m. Eastern time. The Dow plunged 143 points, from 14,697 to 14,554, over the next two minutes. The AP put out a statement at 1:12 p.m. saying that its Twitter account had been hacked and the posting was fake. By 1:19 p.m. the index had recovered all of its losses.

    AP spokesman Paul Colford said the news cooperative is working with Twitter to investigate the issue. The AP disabled its other Twitter accounts following the attack, Colford added.

    Joe Fox, chairman and co-founder of online brokerage Ditto Trade, was at work in Los Angeles when he got a call from his Chicago brokerage offices telling him what had happened. Fox watched the market tanking, and its quick bounce back.

    "It was a topsy-turvy rollercoaster for a few minutes there," Fox said.

    After the brief sell-off, investors turned their focus back to earnings.

    Netflix soared $42.62, or 24 percent, to $216.99 after reporting a big gain in subscribers in the first quarter. Coach jumped $4.96, or 11 percent, to $55.55, after it announced higher sales in North America, better-than-expected earnings and an increased dividend. Travelers rose $1.77, or 2.1 percent, to $86.35. The insurer paid out less in claims compared with the premiums it took in.

    While the shift today was encouraging for the longer-term economic outlook, it may still be too early to form a complete picture.

    Even though 69 percent of companies that have reported earnings for the first quarter have beaten analysts' expectations, profits are expected to rise just 2.3 percent. That is slower than the 7.7 percent growth in the fourth quarter, according to data from S&P Capital IQ.

    And there are still plenty of earnings for investors to get through this week.

    Consumer goods giant Procter & Gamble, drugmaker Eli Lilly and Boeing are among companies that will release earnings on Wednesday. United Parcel Service, Exxon Mobil and Amazon are among the corporations that will give updates on Thursday.

    The Dow closed up 152.29 points at 14,719.46. The S&P 500 ended 16.28 points higher at 1,578.78. Both indexes are about 1 percent below their record highs.

    The Nasdaq composite rose 35.78 points, or 1 percent, to 3,269.33.

    A weaker quarterly earnings outlook from Apple pushed shares down $2.2, or 0.5 percent, to $404.20 in trading after the market closed. Still, the company reported earnings that beat expectations from financial analysts who follow the company.

    Tuesday's upturn in stock markets put both indexes back in the black for April and closer to the record highs they reached on April 11. It was a sharp change of tone from last week, when the market had its worst weekly drop since November. That sell-off started after economic growth in China, the world's second-largest economy, slowed.

    The yield on the 10-year Treasury note rose to 1.71 percent, from 1.70 percent late Monday.

    ___

    AP Business Writer Christina Rexrode contributed.

    Source: http://news.yahoo.com/stocks-gain-earnings-fake-tweet-shakes-stocks-191328789--finance.html

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    Explosion outside French Embassy in Libya highlights security challenges

    The explosion wounded two French guards in what appeared to be the first major terrorist attack on a diplomatic compound in Tripoli since the ouster of Col. Muammar Qaddafi.

    By Sara Miller Llana,?Staff writer / April 23, 2013

    Security officers and officials inspect the site of a car bomb that targeted the French embassy wounding two French guards and causing extensive material damage in Tripoli, Libya, Tuesday. An explosives-laden car was detonated just outside the embassy building in Tripoli's upscale al-Andalus neighborhood, officials said.

    Abdul Majeed Forjani/AP

    Enlarge

    A bomb that exploded outside the French Embassy in Tripoli marks the first time that a diplomatic mission in the Libyan capital has been targeted by terrorists since the take down of?Muammar Qaddafi?in 2011.

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    French President Francois Hollande condemned the act, saying it was an attack not just against France but "all countries in the international community engaged fighting terrorism."

    It is unclear what the motive was and whether there is a link to France?s intervention in Mali or its role in the ouster of the late Mr. Qaddafi.

    No group immediately claimed responsibility for the explosion that wounded two security guards and caused massive damage but no deaths.

    The US ambassador to Libya and three other Americans were killed in Benghazi in a September 2012 attack, but this is described as the first terrorist attack in the capital city against the foreign diplomatic corps. It comes at a time when a new vulnerability to the threat of terrorism, whether domestic or international, has emerged in the wake of the Boston Marathon bombings.

    ?This?is the first time that the capital suffers such an attack. It?s symbolically important because it?s where institutions are ? it [is a message that] these groups can strike pretty much anywhere,? says Karim Bitar,?a?senior research fellow at the Institute for International and Strategic Relations in Paris.?

    According to reports, the blast, an apparent car explosion, blew off the front wall of the embassy and the reception area, as well as the windows in nearby homes in the residential area where the French Embassy of Libya is located.?

    France?s foreign minister, Laurent Fabius, called it an ?odious act? and promised a thorough investigation.?"In conjunction with the Libyan authorities, our government departments will make every effort to ensure that all light be shed on the circumstances of this heinous act and its perpetrators quickly identified," France?s foreign ministry said in a statement.

    Libyan Foreign Minister Mohammed Abdel Aziz condemned the bombing: "We strongly condemn this act, which we regard as a terrorist act against a brother nation that supported Libya during the revolution,? he said.?

    Radical jihadists had promised to retaliate against French interests, after the country?s intervention in Mali this year to drive back Islamist militants there.

    Just this week France?s Parliament voted to extend France?s involvement, which has been widely supported by the French public. France also, under former President Nicolas Sarkozy, took the lead in NATO air raids against Qaddafi?forces, another possible, but less likely, motive, says Mr. Bitar.

    Libya has been mired in violence since then, underscored by the attack this morning. The central authorities have been unable to assert control over dozens of local militias wielding power with various ideologies.?

    ?What it does certainly suggest for France and other European states supporting the transition in Libya is that the number one question is security,? says Susi Dennison,?a policy fellow at the European Council on Foreign Relations.??This has to be a key priority if they want to see its transition emerge successfully.??

    Source: http://rss.csmonitor.com/~r/feeds/csm/~3/H2cQio95gZY/Explosion-outside-French-Embassy-in-Libya-highlights-security-challenges

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    Tuesday, April 23, 2013

    Mont. man reunited with bird he lost in a divorce

    BUTTE, Mont. (AP) ? A Great Falls man who lost his macaw in a divorce more than five years ago has been reunited with the bird, thanks to an observant friend.

    Mike Taylor picked up the 25-year-old bird he calls "Love Love" at Montana's Parrot & Exotic Bird Sanctuary in Butte on Sunday.

    Taylor said his wife sold the bird after a nasty divorce. "I've been kind of looking for him the whole time," he said.

    A friend of Taylor's, Steven Campbell, recently spotted the bird during a visit to the sanctuary.

    It took some time for Campbell to convince Taylor. Then Taylor had to convince sanctuary founder Lori McAlexander. But she said he knew things about the bird that only a previous owner could have known, like it was blind in one eye, said "love love" and liked to play peek-a-boo.

    The bird was surrendered to the sanctuary a couple of years ago after it bit a woman so hard she required medical attention, McAlexander said.

    "I don't even handle him because he will bite me," she said.

    Love Love appeared to recognize Taylor right away.

    "Hangs upside down already, let me grab his beak, does his peeky-boo, likes to tuck his head," said Taylor, who called the reunion "very heart touching."

    "He's himself again already, he really is. I mean, he (didn't) forget."

    Taylor also got the bird's original cage back after searching on Craigslist. A woman who obtained the contents of his ex-wife's storage unit agreed to give him the cage back at no charge.

    "It's kind of weird how he's getting his bird and the cage," McAlexander said.

    Taylor said he initially got the bird at a sanctuary in Salt Lake City after it was rescued from a woman who reportedly beat it with a broom.

    Macaws can live up to 50 years, according to the San Diego Zoo.

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2013-04-22-US-ODD-Man-and-His-Bird/id-ab373e2027624f3eb20e46a0edccac7e

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    U.S. trade panel says Apple did not violate Google patent

    By Diane Bartz

    WASHINGTON (Reuters) - Apple Inc scored a win on Monday when the U.S. International Trade Commission ruled that it did not violate a Google patent to make the popular iPhones.

    Apple had initially been accused of infringing on six patents for iPhone-related technology covering everything from reducing signal noise to programming the device's touch screen so a user's head does not accidentally activate it while talking on the phone.

    If Apple had been found guilty of violating the patent, its devices could have been banned from being imported into the United States.

    Google can appeal the decision to the U.S. Court of Appeals for the Federal Circuit. "We're disappointed with this outcome and are evaluating our options," the company said in a statement. A spokeswoman for Apple declined comment.

    The smartphone industry has seen dozens of lawsuits on several continents as Apple vies for market share with companies that make smartphones that use Google's Android software.

    Google acquired the patents in the case - and the lawsuit - when it purchased Motorola Mobility for $12.5 billion in 2012, partly for its library of telecommunications patents.

    Google's Android software, which the company lets handset makers use for free, has become the world's No. 1 smartphone operating system, ahead of the iOS software used on Apple iPhones.

    The ITC, a U.S. trade panel that investigates patent infringement involving imported goods, is a popular venue for patent lawsuits because it can bar the importation of infringing products and because it issues decisions relatively quickly.

    Motorola Mobility, which has since been acquired by Google, accused Apple in 2010 of infringing on six of its patents. Two were terminated from the case, and the ITC said last August that Apple was innocent of infringing three others.

    But the commission had also asked its internal judge, Thomas Pender, to reconsider its finding that Apple did not violate a fourth patent, which is for a sensor to monitor the location of a user's head to keep it from maneuvering on the touch screen. Pender found that patent obvious in December, and the full ITC came to the same conclusion on Monday.

    The case in the ITC is In the Matter of Certain Wireless Communication Devices, Portable Music and Data Processing Devices, Computers and Components Thereof, 337-745.

    (Reporting by Diane Bartz; editing by Ros Krasny and Phil Berlowitz)

    Source: http://news.yahoo.com/u-trade-panel-says-apple-did-not-violate-102238352--sector.html

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    PFT: Revis to Bucs done? |? Six-year contract

    Jimmy HaslamGetty Images

    Browns owner Jimmy Haslam apparently has received ? and is heeding ? advice from his lawyers regarding the fact that anything he says can and will be used against him, if/when he personally faces charges for fraud allegedly committed by the billion-dollar, family-owned truck-stop company he runs.

    As a result, Haslam met with the media again on Monday, but instead of speaking extemporaneously and then answering questions, he read from a lengthy prepared statement that surely was written or at least reviewed and revised by one or more lawyers.

    Mary Kay Cabot of the Cleveland Plain Dealer has the full text of the statement, which says nothing about the Browns.? While the smartest move at this point would be to say nothing at all about anything, Haslam realizes that his customers could scatter and his employees could flee and the entire operation could disintegrate without real efforts to hold the business together.

    But in starting the process of rebuilding trust and restoring confidence, Haslam comes dangerously close to admitting that improprieties occurred.? For example, in explaining that the company will now have a ?Chief Compliance Officer,? Haslam basically acknowledges that, if whoever blew the whistle to the feds had a way to blow the whistle internally, the whole thing could have been fixed without outside scrutiny.

    ?The establishment of a position of Chief Compliance Officer is important, because had we had one before, perhaps some team member would have raised a question about manual rebates internally before anyone would ever have gone to federal investigators,? Haslam said.

    Haslam also continues to emphasize that the situation affects only a ?narrow? portion of the company?s business.? But with 3,300 trucking-company customers, a lot of fraud can still happen to a ?narrow? band of customers.? Reciting instances of compliance with the lawyer is never a defense to the specific instances when the law was broken.

    Most significantly, Haslam explained that the company placed on ?administrative leave several members of our diesel fuel team.?? Presumably, that includes V.P. of sales John Freeman, whose colorful and profane terms were caught on tape by an informant, along with an admission that Haslam was aware of the alleged rebate scam.

    If/when Freeman agrees to testify against Haslam, Haslam will have a serious problem; in the interim, Haslam and his lawyers necessarily must commence preparations for painting this once-trusted employee as inherently unreliable, especially as to anything he would say under oath about Haslam.

    Of course, none of it matters if Pilot Flying J ends up being driven into the ground by the loss of customers and personnel.? Haslam?s statement from Monday is aimed at keeping that from happening.

    Source: http://profootballtalk.nbcsports.com/2013/04/21/jets-most-likely-will-get-a-third-round-pick-in-2014-for-revis/related/

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    Monday, April 22, 2013

    In Paraguay, a rich conservative must tackle poverty

    By Daniela Desantis and Hilary Burke

    ASUNCION (Reuters) - For Horacio Cartes, a millionaire cigarette and soft drink magnate who will be Paraguay's next president, the challenge now is to run a country where most people can only dream of having a sliver of the wealth he does.

    The 56-year-old, who won election on Sunday with 46 percent of the vote and will take office in August, campaigned as a center-right conservative at a time when most of Latin America is run by leftists.

    Indeed, Cartes has touted a pro-business agenda that includes modernizing the bloated state, which employs about 10 percent of all workers in Paraguay. At a news conference on Monday, he said the state's "main responsibility is to create an environment so that the private sector can work with calm."

    He also wants to attract up to $2.7 billion in private capital to refurbish Paraguay's airports and build new highways.

    "We have to try to make investments in infrastructure without growing our mass of public workers," he said on Monday.

    Yet it may not be quite that easy.

    Cartes himself has acknowledged that, to be successful, he must also cater to Paraguay's poor masses. Poverty runs near 40 percent and per-capita gross domestic product was just $5,413 in 2011, the second-lowest in South America behind only Bolivia, according to International Monetary Fund data.

    The country of 6.6 million has long been one of the region's most politically unstable, with a fragile economy dependent on agriculture. The last elected president, Fernando Lugo, was impeached last year following civil unrest.

    A political novice who never voted before 2009, Cartes will have strong support from Congress, but will also have to sustain the support of his center-right Colorado Party, whose 60-year reign was interrupted by Lugo's election in 2008.

    On Sunday, the Colorado Party won control of the lower house and 19 of 45 Senate seats, preliminary election results showed. The Liberals had the second-biggest showing and leftist coalitions came in third place, with Lugo elected senator.

    Cartes has promised to reform the Colorado Party, infamous for corruption and whose long period in power included General Alfredo Stroessner's 1954-1989 dictatorship. But some in the party will likely push back against change.

    "It's very difficult to know what Cartes wants to do," said political analyst Jose Carlos Rodriguez.

    "In principle, he has a neo-conservative project that gives a strong impulse to private companies and nothing to the state. But there's a major inconsistency there and he'll also have a powerful party that will demand certain benefits."

    NOTORIOUS FOR CONTRABAND

    Paraguay relies heavily on soybean and beef exports but it is also notorious for contraband trade and money laundering. Growth is seen at 13 percent this year after a severe drought caused a contraction in 2012, according to the central bank.

    Land conflicts have intensified in recent years and the small, violent left-wing Paraguayan People's Army operates in northern regions.

    In January, the Liberal government took an unprecedented step to tap global debt markets, selling $500 million in 10-year bonds that were nearly 12 times oversubscribed.

    Cartes expressed misgivings on Monday over the bond, saying the issue was a "very positive step" but that the money could not be used on salaries or other fixed costs that would "grow the daddy state."

    On Monday, Paraguay's global bond was trading largely steady. A New York-based trader said it was yielding at 4.37 percent, or 26 basis points tighter than when it was first issued at par, but he said the paper was very illiquid.

    Latin America's leftist bloc is especially strong in the Mercosur trade group, which includes Brazil, Argentina, Venezuela and Uruguay. Mercosur suspended Paraguay in June when Lugo was ousted, arguing the two-day impeachment trial was tantamount to a coup.

    Soon after, Mercosur brought in socialist Venezuela even though its inclusion was never approved by Paraguay's Congress.

    Cartes told reporters on Sunday that he had already made contacts with Mercosur officials to ensure Paraguay's full return to the group. The presidents of Argentina and Uruguay welcomed Paraguay back into the fold after Cartes' victory.

    Fiona Mackie, Paraguay analyst at The Economist Intelligence Unit research firm, said she did not think Cartes would pursue plans to open airports and state utilities to private investment due to resistance within the Colorado Party.

    "That said, a Cartes government would be relatively open to foreign investment in mineral resources," she wrote last week, noting the recent discovery of a major titanium deposit and plans for an aluminum smelter by Rio Tinto Alcan.

    (Additional reporting by Mariel Cristaldo and Joan Magee for IFR in New York; Editing by Brian Winter, Eric Walsh and Vicki Allen)

    Source: http://news.yahoo.com/paraguay-rich-conservative-must-now-tackle-poverty-200844066--business.html

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    Thursday, April 18, 2013

    Doctors flee Puerto Rico for US mainland

    A doctor walks through a hallway at the Centro Medico trauma center in San Juan, Puerto Rico, Tuesday, April 16, 2013. A medical exodus is taking place in the Caribbean territory as doctors and nurses flee for the U.S. mainland, seeking higher salaries and better reimbursements from insurers. Many of their patients, frustrated by long waits and a scarcity of specialists, are finding they have no other choice but to follow them off the island. (AP Photo/Ricardo Arduengo)

    A doctor walks through a hallway at the Centro Medico trauma center in San Juan, Puerto Rico, Tuesday, April 16, 2013. A medical exodus is taking place in the Caribbean territory as doctors and nurses flee for the U.S. mainland, seeking higher salaries and better reimbursements from insurers. Many of their patients, frustrated by long waits and a scarcity of specialists, are finding they have no other choice but to follow them off the island. (AP Photo/Ricardo Arduengo)

    (AP) ? Going to the doctor in Puerto Rico has for years often meant getting in line. Now, it might mean getting on a plane.

    A medical exodus is taking place in the Caribbean territory as doctors and nurses flee for the U.S. mainland, seeking higher salaries and better reimbursement from insurers. Many of their patients, frustrated by long waits and a scarcity of specialists, are finding they have no choice but to follow them off the island.

    Among them is Marilu Flores, a 60-year-old rural mail carrier who is battling advanced rheumatoid arthritis.

    She not only is flying to the U.S. mainland to receive treatment; she's moving to Texas.

    "The best doctors left a long time ago," she said.

    In the last five years, the number of doctors in Puerto Rico has dropped by 13 percent, from 11,397 to 9,950, according to the island's Medical Licensing and Studies Board. The biggest losses are primary care physicians and specialists within a specialty, such as thoracic oncologists.

    Of the roughly 400 cardiologists who practiced in Puerto Rico about five years ago, only about 150 remain. The number of anesthesiologists has dropped from roughly 300 to about 100 in roughly the same time period, said Dr. Eduardo Ibarra, president of the island's Association of Surgeons.

    "Same with the neurosurgeons. They don't even number 20 now," Ibarra said. "There are no specialized surgeons in certain areas."

    Those seeking a thoracic oncologist, for example, have to go to Florida, if they can afford it.

    "It's truly catastrophic," he said.

    The exodus of doctors is part of a larger wave of professionals who have left the U.S. island territory in recent years, settling in states such as Florida and New York, where there is a big demand for bilingual workers, especially police and nurses. Many Puerto Ricans also seek to escape a wave of violent crime and higher cost of living. Almost a million more Puerto Ricans now live on the mainland than on the island.

    Medical professionals say they expect the situation will worsen.

    President Barack Obama's new health care law means U.S. states will soon seek more doctors amid an influx of patients, said Dr. Guillermo Tirado, an internal medicine specialist in Puerto Rico.

    "All states are preparing to cull a lot of doctors from Puerto Rico," he said. "If we have a big exodus now, we're going to see it get worse ... There hasn't been a revolution yet because the escape valve is to buy a plane ticket to Orlando," referring to the many patients who fly to the U.S. for treatment if they can afford it.

    Puerto Rico currently does not meet federal recommendations on the number and types of doctors needed per capita, Tirado said.

    The island of 3.7 million people has no more than two pediatric neurosurgeons, even though guidelines state there should be at least one pediatric neurosurgeon per roughly 80,000 people, he said.

    Puerto Rico also lacks 93 full-time primary care physicians to adequately cover the medical needs of the population, according to statistics from the U.S. Health Resources and Services Administration, which tracks areas suffering from a shortage of health professionals. Of the island's 78 municipalities, 37 need more health care professionals, including the capital of San Juan and Ponce, the island's second largest city. The island has roughly 7,000 primary care physicians, Ibarra said.

    At the same time, the island's medical tourism industry is growing, with two new hospitals being built in Manati and Bayamon, catering mostly to foreigners from elsewhere in the Caribbean, and even some from the U.S. mainland, said Pedro Pierluisi, the island's representative in Congress who has limited voting powers. "In a way, it's inconsistent," he said.

    Tirado said U.S. patients seek mostly cosmetic procedures, while Caribbean patients often seek specialists not available on their islands, such as endocrinologists.

    "It's a paradox," he said, noting that U.S. tourists who need other medical services while on vacation often choose to go back to the mainland in an air ambulance.

    To prevent doctors from leaving, one legislator has introduced a bill that would require medical students to stay and practice in Puerto Rico the amount of time it took to complete their residency if the government paid for it.

    "We're being left without specialists," said Jose Aponte, former president of the House of Representatives.

    The government pays for the residencies of at least 95 percent of all Puerto Rican medical students, investing $35,000-$45,000 a year for each, Aponte said. Puerto Rico has four medical schools, and roughly 400 medical students graduate a year.

    If the bill is approved, students would have to reimburse the government the cost of their residency if they leave before practicing medicine for the required time.

    "Currently, they are disappearing from the scene because they go to the U.S., where they have received incredible offers," he said.

    Tirado agreed: "Job offers rain down every day," he said. "It's a huge bombardment."

    Family and general practitioners in Puerto Rico earn about $72,000 a year, while in the U.S. they earn about $180,000, according to 2012 statistics from the U.S. Bureau of Labor.

    That's partly due to the lower standard of wages on the island, where the median wage is less than $28,000 a year, far below mainland income. Ibarra and Tirado say peculiarities in the island's health insurance system also force doctors to accept less income ? or to leave.

    Puerto Rican health care providers also get less reimbursement from Medicare for particular services than do those in any other U.S. state or territory, Pierluisi said. They get about 20 percent less than those on the U.S. Virgin Islands and the base rate for hospital patients is 14 percent less than on the U.S. mainland, he said.

    Currently, more than 670,000 people in Puerto Rico use Medicare.

    "It's a huge number of patients for doctors," said Pierluisi. "It's the best plan we have. It serves as the top plan. If Medicare is not paying our physicians well, the commercial insurers in the private sector will do the same."

    While the U.S. government is scheduled to revise how Medicare reimbursements are determined next year, that won't stop doctors from leaving, Tirado said.

    A recent study commissioned by the island's Association of Surgeons found the problem is aggravated by retiring doctors, and by the fact that fewer doctors are studying allergy, endocrinology, geriatrics and urology. The study also warned about a scarcity of specialists including cardiologists, anesthesiologists and orthopedic surgeons.

    Flores said she is looking forward to not having to worry about scarcity of doctors once she moves to the U.S.

    "I've already taken the decision to quit my job," she said. "It pays well, but my health is more important."

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-17-CB-Puerto-Rico-Doctor-Exodus/id-0fce024f615f4bbea2323e472388b40d

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    Wednesday, April 17, 2013

    Acute stress primes brain for better cognitive and mental performance

    Apr. 16, 2013 ? Overworked and stressed out? Look on the bright side. Some stress is good for you.

    "You always think about stress as a really bad thing, but it's not," said Daniela Kaufer, associate professor of integrative biology at the University of California, Berkeley. "Some amounts of stress are good to push you just to the level of optimal alertness, behavioral and cognitive performance."

    New research by Kaufer and UC Berkeley post-doctoral fellow Elizabeth Kirby has uncovered exactly how acute stress -- short-lived, not chronic -- primes the brain for improved performance.

    In studies on rats, they found that significant, but brief stressful events caused stem cells in their brains to proliferate into new nerve cells that, when mature two weeks later, improved the rats' mental performance.

    "I think intermittent stressful events are probably what keeps the brain more alert, and you perform better when you are alert," she said.

    Kaufer, Kirby and their colleagues in UC Berkeley's Helen Wills Neuroscience Institute describe their results in a paper published April 16 in the new open access online journal eLife.

    The UC Berkeley researchers' findings, "in general, reinforce the notion that stress hormones help an animal adapt -- after all, remembering the place where something stressful happened is beneficial to deal with future situations in the same place," said Bruce McEwen, head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at The Rockefeller University, who was not involved in the study.

    Kaufer is especially interested in how both acute and chronic stress affect memory, and since the brain's hippocampus is critical to memory, she and her colleagues focused on the effects of stress on neural stem cells in the hippocampus of the adult rat brain. Neural stem cells are a sort of generic or progenitor brain cell that, depending on chemical triggers, can mature into neurons, astrocytes or other cells in the brain. The dentate gyrus of the hippocampus is one of only two areas in the brain that generate new brain cells in adults, and is highly sensitive to glucocorticoid stress hormones, Kaufer said.

    Much research has demonstrated that chronic stress elevates levels of glucocorticoid stress hormones, which suppresses the production of new neurons in the hippocampus, impairing memory. This is in addition to the effect that chronically elevated levels of stress hormones have on the entire body, such as increasing the risk of chronic obesity, heart disease and depression.

    Less is known about the effects of acute stress, Kaufer said, and studies have been conflicting.

    To clear up the confusion, Kirby subjected rats to what, to them, is acute but short-lived stress -- immobilization in their cages for a few hours. This led to stress hormone (corticosterone) levels as high as those from chronic stress, though for only a few hours. The stress doubled the proliferation of new brain cells in the hippocampus, specifically in the dorsal dentate gyrus.

    Kirby discovered that the stressed rats performed better on a memory test two weeks after the stressful event, but not two days after the event. Using special cell labeling techniques, the researchers established that the new nerve cells triggered by the acute stress were the same ones involved in learning new tasks two weeks later.

    "In terms of survival, the nerve cell proliferation doesn't help you immediately after the stress, because it takes time for the cells to become mature, functioning neurons," Kaufer said. "But in the natural environment, where acute stress happens on a regular basis, it will keep the animal more alert, more attuned to the environment and to what actually is a threat or not a threat."

    They also found that nerve cell proliferation after acute stress was triggered by the release of a protein, fibroblast growth factor 2 (FGF2), by astrocytes -- brain cells formerly thought of as support cells, but that now appear to play a more critical role in regulating neurons.

    "The FGF2 involvement is interesting, because FGF2 deficiency is associated with depressive-like behaviors in animals and is linked to depression in humans," McEwen said.

    Kaufer noted that exposure to acute, intense stress can sometimes be harmful, leading, for example, to post-traumatic stress disorder. Further research could help to identify the factors that determine whether a response to stress is good or bad.

    "I think the ultimate message is an optimistic one," she concluded. "Stress can be something that makes you better, but it is a question of how much, how long and how you interpret or perceive it."

    The eLife paper was coauthored by UC Berkeley colleagues Sandra E Muroy, Wayne G. Sun and David Covarrubias of the Department of Molecular and Cell Biology; Megan J. Leong of the Helen Wills Neuroscience Institute; and Laurel A. Barchas of the Department of Integrative Biology. Kirby is now a post-doctoral fellow at Stanford University.

    Kaufer's research was funded by a BRAINS (Biobehavioral Research Awards for Innovative New Scientists) award from the National Institute of Mental Health of the National Institutes of Health (R01 MH087495) and the National Alliance for Research on Schizophrenia and Depression. Kirby was supported by fellowships from the California Institute for Regenerative Medicine and the U.S. Department of Defense.

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    Story Source:

    The above story is reprinted from materials provided by University of California - Berkeley. The original article was written by Robert Sanders.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Elizabeth D Kirby, Sandra E Muroy, Wayne G Sun, David Covarrubias, Megan J Leong, Laurel A Barchas, Daniela Kaufer. Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife, April 16, 2013

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/mental_health/~3/99sVXZ3MXWo/130416204546.htm

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    Sunday, April 14, 2013

    Do drugs for bipolar disorder 'normalize' brain gene function?

    Friday, April 12, 2013

    Every day, millions of people with bipolar disorder take medicines that help keep them from swinging into manic or depressed moods. But just how these drugs produce their effects is still a mystery.

    Now, a new University of Michigan Medical School study of brain tissue helps reveal what might actually be happening. And further research using stem cells programmed to act like brain cells is already underway.

    Using genetic analysis, the new study suggests that certain medications may help "normalize" the activity of a number of genes involved in communication between brain cells. It is published in the current issue of Bipolar Disorders.

    The study involved brain tissue from deceased people with and without bipolar disorder, which the U-M team analyzed to see how often certain genes were activated, or expressed. Funding support came from the National Institutes of Health and the Heinz C. Prechter Bipolar Research Fund.

    "We found there are hundreds of genes whose activity is adjusted in individuals taking medication ? consistent with the fact that there are a number of genes that are potentially amiss in people with bipolar," says senior author Melvin McInnis, M.D., the U-M psychiatrist, U-M Depression Center member and principal investigator of the Prechter Fund Projects who helped lead the study. "Taking the medications, specifically ones in a class called antipsychotics, seemed to normalize the gene expression pattern in these individuals so that it approached that of a person without bipolar."

    Digging deeper into bipolar genetics

    Scientists already know that bipolar disorder's roots lie in genetic differences in the brain -- though they are still searching for the specific gene combinations involved.

    McInnis and his colleagues have now embarked on research developing several a lines of induced pluripotent stem cells derived (iPSC) from volunteers with and without bipolar disorder, which will allow even more in-depth study of the development and genetics of bipolar disorder.

    The newly published study looked at the expression, or activity levels, of 2,191 different genes in the brains of 14 people with bipolar disorder, and 12 with no mental health conditions. The brains were all part of a privately funded nonprofit brain bank that collected and stored donated brains, and recorded what medications the individuals were taking at the time of death.

    Seven of the brains were from people with bipolar disorder who had been taking one or more antipsychotics when they died. These drugs include clozapine, risperidone, and haloperidol, and are often used to treat bipolar disorder. Most of the 14 brain donors with bipolar disorder were also taking other medications, such as antidepressants, at the time of death.

    When the researchers compared the gene activity patterns among the brains of bipolar disorder patients who had been exposed to antipsychotics with patterns among those who weren't, they saw striking differences.

    Then, when they compared the activity patterns of patients who had been taking antipsychotics with those of people without bipolar disorder, they found similar patterns.

    The similarities were strongest in the expression of genes involved in the transmission of signals across synapses ? the gaps between brain cells that allow cells to 'talk' to one another. There were also similarities in the organization of nodes of Ranvier ? locations along nerve cells where signals can travel faster.

    McInnis, who is the Thomas B. and Nancy Upjohn Woodworth Professor of Bipolar Disorder and Depression in the U-M Department of Psychiatry, worked with U-M scientists Haiming Chen, M.D. and K. Sue O'Shea, Ph.D., of the U-M Department of Cell and Developmental Biology. They also teamed with Johns Hopkins University researcher Christopher Ross, M.D., Ph.D. on the new research; U-M and Johns Hopkins have a long history of collaboration on bipolar disorder research.

    The research used brain tissue samples from the Stanley Brain Collection of the Stanley Medical Research Institute in Maryland.

    Using "gene chip" analysis to measure the presence of messenger RNA molecules that indicate gene activity, and sophisticated data analysis, they were able to map the expression patterns from the brains and break the results down by bipolar status and medication use. The bipolar and control (non-bipolar) brains were matched by age, gender and other factors.

    "In bipolar disorder, it's not just one gene that's involved ? it's a whole symphony of them," says McInnis, who has helped lead U-M's bipolar genetics research for nearly a decade. "Medications appear to nudge them in a direction that aligns more with the normal expression pattern."

    Among those that were "nudged" were genes that have already been shown to be linked to bipolar disorder, including glycogen synthase kinase 3 beta (GSK3?), FK506 binding protein 5 (FKBP5), and Ankyrin 3 (ANK3).

    Going forward, says McInnis, cell culture studies will be critical to studying how medications for bipolar disorder work, and to screen new molecules as potential new medications.

    ###

    University of Michigan Health System: http://www.med.umich.edu

    Thanks to University of Michigan Health System for this article.

    This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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    Source: http://www.labspaces.net/127728/Do_drugs_for_bipolar_disorder__normalize__brain_gene_function_

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